Acridone alkaloids from Zanthoxylum zanthoxyloides potentiate the antifungal activity of voriconazole, nystatin and caspofungin

Fungal infections are a significant global healthcare problem causing more deaths annually than tuberculosis or malaria. The study investigated the antifungal activity of arborinine and fabiocinine, isolated from Zanthoxylum zanthoxyloides, against fluconazole-resistant Candida albicans and Candida glabrata, and assessed their ability to potentiate the effect of clinically used antifungals, voriconazole, nystatin and caspofungin, against the resistant Candida species.